Formation of DNA adducts by formaldehyde-activated mitoxantrone.

Recent studies with the anthracycline Adriamycin have demonstrated its activation by formaldehyde and subsequent binding to DNA in vitro. Since formaldehyde levels are known to be higher in cells of myeloid origin and the structurally related drug mitoxantrone is most effective against cancers of my...

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Bibliografiske detaljer

Udgivet i:	Nucleic Acids Res
Principais autores:	Parker, B S, Cullinane, C, Phillips, D R
Format:	Artigo
Sprog:	Inglês
Udgivet:	Oxford University Press 1999
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148507/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10390534/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.14.2918
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