Formation of DNA adducts by formaldehyde-activated mitoxantrone.
Recent studies with the anthracycline Adriamycin have demonstrated its activation by formaldehyde and subsequent binding to DNA in vitro. Since formaldehyde levels are known to be higher in cells of myeloid origin and the structurally related drug mitoxantrone is most effective against cancers of my...
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| Pubblicato in: | Nucleic Acids Res |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
1999
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148507/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10390534/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.14.2918 |
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