Formation of DNA adducts by formaldehyde-activated mitoxantrone.

Recent studies with the anthracycline Adriamycin have demonstrated its activation by formaldehyde and subsequent binding to DNA in vitro. Since formaldehyde levels are known to be higher in cells of myeloid origin and the structurally related drug mitoxantrone is most effective against cancers of my...

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Vydáno v:	Nucleic Acids Res
Hlavní autoři:	Parker, B S, Cullinane, C, Phillips, D R
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Oxford University Press 1999
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148507/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10390534/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.14.2918
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