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Mechanisms of DNA sequence selective alkylation of guanine-N7 positions by nitrogen mustards.

Quantitative determinations were carried out of the relative reaction rates of several nitrogen mustards at various guanine-N7 positions in DNA fragments of known sequence. The findings suggest structural hypotheses of the origins of the reaction selectivities. End-labeled DNA fragments were reacted...

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Detalhes bibliográficos
Main Authors: Kohn, K W, Hartley, J A, Mattes, W B
Formato: Artigo
Idioma:Inglês
Publicado em: 1987
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC339961/
https://ncbi.nlm.nih.gov/pubmed/3697095
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