DNA sequence-specific adenine alkylation by the novel antitumor drug tallimustine (FCE 24517), a benzoyl nitrogen mustard derivative of distamycin.

FCE 24517, a novel distamycin derivative possessing potent antitumor activity, is under initial clinical investigation in Europe. In spite of the presence of a benzoyl nitrogen mustard group this compound fails to alkylate the N7 position of guanine, the major site of alkylation by conventional nitr...

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Εκδόθηκε σε:	Nucleic Acids Res
Κύριοι συγγραφείς:	Broggini, M, Coley, H M, Mongelli, N, Pesenti, E, Wyatt, M D, Hartley, J A, D'Incalci, M
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Oxford University Press 1995
Θέματα:	Research Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC306633/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7870593/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.1.81
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