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DNA sequence-specific adenine alkylation by the novel antitumor drug tallimustine (FCE 24517), a benzoyl nitrogen mustard derivative of distamycin.

FCE 24517, a novel distamycin derivative possessing potent antitumor activity, is under initial clinical investigation in Europe. In spite of the presence of a benzoyl nitrogen mustard group this compound fails to alkylate the N7 position of guanine, the major site of alkylation by conventional nitr...

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Udgivet i:Nucleic Acids Res
Principais autores: Broggini, M, Coley, H M, Mongelli, N, Pesenti, E, Wyatt, M D, Hartley, J A, D'Incalci, M
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC306633/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7870593/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/23.1.81
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