Active Site-labeled Prothrombin Inhibits Prothrombinase in Vitro and Thrombosis in Vivo

Mouse and human prothrombin (ProT) active site specifically labeled with d-Phe-Pro-Arg-CH(2)Cl (FPR-ProT) inhibited tissue factor-initiated thrombin generation in platelet-rich and platelet-poor mouse and human plasmas. FPR-prethrombin 1 (Pre 1), fragment 1 (F1), fragment 1.2 (F1.2), and FPR-thrombi...

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Main Authors: Kroh, Heather K., Panizzi, Peter, Tchaikovski, Svetlana, Baird, T. Regan, Wei, Nancy, Krishnaswamy, Sriram, Tans, Guido, Rosing, Jan, Furie, Bruce, Furie, Barbara C., Bock, Paul E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2011
Ábhair:
Enzymology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123099/
https://ncbi.nlm.nih.gov/pubmed/21531712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.230292
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