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Visualization of the nanospring dynamics of the IκBα ankyrin repeat domain in real time
IκBα is a crucial regulator of NFκB transcription. NFκB-mediated gene activation is robust because levels of free IκBα are kept extremely low by rapid, ubiquitin-independent degradation of newly synthesized IκBα. IκBα has a weakly folded ankyrin repeat 5–6 (AR5–6) region that is critical in establis...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3121830/ https://ncbi.nlm.nih.gov/pubmed/21628581 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102226108 |
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