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Long-Range Effects and Functional Consequences of Stabilizing Mutations in the Ankyrin Repeat Domain of IκBα
Protein domains containing three or more ankyrin repeats (ARs) are ubiquitous in all phyla. Sequence alignments previously identified certain conserved positions, which have been shown to stabilize AR domains and promote their folding. Consensus mutations [Y254L/T257A (YLTA) and C186P/A220P (CPAP)]...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3744861/ https://ncbi.nlm.nih.gov/pubmed/23274114 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.12.012 |
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