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Detection of a ternary complex of NF-κB and IκBα with DNA provides insights into how IκBα removes NF-κB from transcription sites

It has been axiomatic in the field of NF-κB signaling that the formation of a stable complex between NF-κB and the ankyrin repeat protein IκBα precludes the interaction of NF-κB with DNA. Contradicting this assumption, we present stopped-flow fluorescence and NMR experiments that give unequivocal ev...

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Detalhes bibliográficos
Main Authors: Sue, Shih-Che, Alverdi, Vera, Komives, Elizabeth A., Dyson, H. Jane
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029698/
https://ncbi.nlm.nih.gov/pubmed/21220295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1014323108
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