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Structural characterization of the ternary complex that mediates termination of NF-κB signaling by IκBα

The transcription factor NF-κB is used in many systems for the transduction of extracellular signals into the expression of signal-responsive genes. Published structural data explain the activation of NF-κB through degradation of its dedicated inhibitor IκBα, but the mechanism by which NF-κB–mediate...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Mukherjee, Sulakshana P., Quintas, Pedro O., McNulty, Reginald, Komives, Elizabeth A., Dyson, H. Jane
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896678/
https://ncbi.nlm.nih.gov/pubmed/27185953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1603488113
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