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Interaction of the IκBα C-terminal PEST sequence with NF-κB: Insights into the Inhibition of NF-κB DNA binding by IκBα

The transcription factor NF-κB (p50/p65) binds either a κB DNA element or its inhibitor protein, IκBα, but these two binding events are mutually exclusive. The reason for this exclusivity is not obvious from the available crystal structure data. The C-terminal PEST-like sequence of IκBα appears to b...

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Detalhes bibliográficos
Main Authors: Sue, Shih-Che, Dyson, H. Jane
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2688455/
https://ncbi.nlm.nih.gov/pubmed/19327364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.03.048
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