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Interaction of the IκBα C-terminal PEST sequence with NF-κB: Insights into the Inhibition of NF-κB DNA binding by IκBα
The transcription factor NF-κB (p50/p65) binds either a κB DNA element or its inhibitor protein, IκBα, but these two binding events are mutually exclusive. The reason for this exclusivity is not obvious from the available crystal structure data. The C-terminal PEST-like sequence of IκBα appears to b...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2688455/ https://ncbi.nlm.nih.gov/pubmed/19327364 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.03.048 |
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