High Affinity Small Protein Inhibitors of Human Chymotrypsin C (CTRC) Selected by Phage Display Reveal Unusual Preference for P4′ Acidic Residues

Human chymotrypsin C (CTRC) is a pancreatic protease that participates in the regulation of intestinal digestive enzyme activity. Other chymotrypsins and elastases are inactive on the regulatory sites cleaved by CTRC, suggesting that CTRC recognizes unique sequence patterns. To characterize the mole...

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Detalhes bibliográficos
Main Authors: Szabó, András, Héja, Dávid, Szakács, Dávid, Zboray, Katalin, Kékesi, Katalin A., Radisky, Evette S., Sahin-Tóth, Miklós, Pál, Gábor
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121398/
https://ncbi.nlm.nih.gov/pubmed/21515688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.235754
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