High Affinity Small Protein Inhibitors of Human Chymotrypsin C (CTRC) Selected by Phage Display Reveal Unusual Preference for P4′ Acidic Residues

Human chymotrypsin C (CTRC) is a pancreatic protease that participates in the regulation of intestinal digestive enzyme activity. Other chymotrypsins and elastases are inactive on the regulatory sites cleaved by CTRC, suggesting that CTRC recognizes unique sequence patterns. To characterize the mole...

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Hlavní autoři: Szabó, András, Héja, Dávid, Szakács, Dávid, Zboray, Katalin, Kékesi, Katalin A., Radisky, Evette S., Sahin-Tóth, Miklós, Pál, Gábor
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Enzymology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121398/
https://ncbi.nlm.nih.gov/pubmed/21515688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.235754
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