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Inactivation of mesotrypsin by chymotrypsin C prevents trypsin inhibitor degradation
Mesotrypsin is an unusual human trypsin isoform with inhibitor resistance and the ability to degrade trypsin inhibitors. Degradation of the protective serine protease inhibitor Kazal type 1 (SPINK1) by mesotrypsin in the pancreas may contribute to the pathogenesis of pancreatitis. Here we tested the...
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| 發表在: | J Biol Chem |
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| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7076226/ https://ncbi.nlm.nih.gov/pubmed/32014997 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012526 |
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