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Mesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis

Human chymotrypsin C (CTRC) protects against pancreatitis by degrading trypsinogen and thereby curtailing harmful intra-pancreatic trypsinogen activation. Loss-of-function mutations in CTRC increase the risk for chronic pancreatitis. Here we describe functional analysis of eight previously uncharact...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Szabó, András, Ludwig, Maren, Hegyi, Eszter, Szépeová, Renata, Witt, Heiko, Sahin-Tóth, Miklós
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4498067/
https://ncbi.nlm.nih.gov/pubmed/26013824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.618439
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