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Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk

OBJECTIVE: The digestive enzyme chymotrypsin C (CTRC) protects against pancreatitis by promoting degradation of trypsinogen and thereby curtailing potentially harmful trypsinogen activation. Loss-of-function variants in CTRC increase the risk for chronic pancreatitis. The aim of the present study wa...

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Detalhes bibliográficos
Main Authors: Beer, Sebastian, Zhou, Jiayi, Szabó, András, Keiles, Steven, Chandak, Giriraj Ratan, Witt, Heiko, Sahin-Tóth, Miklós
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3660471/
https://ncbi.nlm.nih.gov/pubmed/22942235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2012-303090
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