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Increased Activation of Hereditary Pancreatitis-associated Human Cationic Trypsinogen Mutants in Presence of Chymotrypsin C

Mutations in human cationic trypsinogen (PRSS1) cause autosomal dominant hereditary pancreatitis. Increased intrapancreatic autoactivation of trypsinogen mutants has been hypothesized to initiate the disease. Autoactivation of cationic trypsinogen is proteolytically regulated by chymotrypsin C (CTRC...

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Detalhes bibliográficos
Main Authors: Szabó, András, Sahin-Tóth, Miklós
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370252/
https://ncbi.nlm.nih.gov/pubmed/22539344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.360065
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