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Increased Activation of Hereditary Pancreatitis-associated Human Cationic Trypsinogen Mutants in Presence of Chymotrypsin C

Mutations in human cationic trypsinogen (PRSS1) cause autosomal dominant hereditary pancreatitis. Increased intrapancreatic autoactivation of trypsinogen mutants has been hypothesized to initiate the disease. Autoactivation of cationic trypsinogen is proteolytically regulated by chymotrypsin C (CTRC...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Szabó, András, Sahin-Tóth, Miklós
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2012
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370252/
https://ncbi.nlm.nih.gov/pubmed/22539344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.360065
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