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Chymotrypsin Reduces the Severity of Secretagogue-induced Pancreatitis in Mice

Intra-pancreatic activation of the digestive proteases trypsin and chymotrypsin is an early event in the development of pancreatitis. Human genetic studies indicate that chymotrypsin controls trypsin activity via degradation, but there is no evidence of this from animal models. We used CRISPR-Cas9 t...

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Bibliografiske detaljer
Udgivet i:Gastroenterology
Main Authors: Jancsó, Zsanett, Hegyi, Eszter, Sahin-Tóth, Miklós
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6200337/
https://ncbi.nlm.nih.gov/pubmed/30076839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2018.06.041
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