THE SUGAR RING CONFORMATION OF 4’-ETHYNYL-2-FLUORO-2’-DEOXYADENOSINE AND ITS RECOGNITION BY THE POLYMERASE ACTIVE SITE OF HIV REVERSE TRANSCRIPTASE

4’-Ethynyl-2-fluoro-2’-deoxyadenosine (EFdA) is the most potent inhibitor of HIV reverse transcriptase (RT). We have recently named EFdA a Translocation Defective RT Inhibitor (TDRTI) because after its incorporation in the nucleic acid it blocks DNA polymerization, primarily by preventing translocat...

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Autores principales: Kirby, K.A., Singh, K., Michailidis, E., Marchand, B., Kodama, E.N., Ashida, N., Mitsuya, H., Parniak, M.A., Sarafianos, S.G.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3119259/
https://ncbi.nlm.nih.gov/pubmed/21366961
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