p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels

We synthesized the R- and S-enantiomers of ethyl 1-(1-(4-(3-((trifluoromethyl)-3H-diazirin-3-yl)phenyl)ethyl)-1H-imidazole-5-carboxylate (trifluromethyldiazirinyl-etomidate), or TFD-etomidate, a novel photoactivable derivative of the stereoselective general anesthetic etomidate (R-(2-ethyl 1-(phenyl...

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Bibliografiset tiedot
Päätekijät: Husain, S. Shaukat, Stewart, Deirdre, Desai, Rooma, Hamouda, Ayman K., Li, S. Guo-Dong, Kelly, Elizabeth, Dostalova, Zuzana, Zhou, Xiaojuan, Cotten, Joseph F., Raines, Douglas A., Olsen, Richard W., Cohen, Jonathan B., Forman, Stuart A., Miller, Keith W.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2010
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117435/
https://ncbi.nlm.nih.gov/pubmed/20704351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100498u
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