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Location Trumps Length: Polyglutamine-Mediated Changes in Folding and Aggregation of a Host Protein
Expanded CAG diseases are progressive neurodegenerative disorders in which specific proteins have an unusually long polyglutamine stretch. Although these proteins share no other sequence or structural homologies, they all aggregate into intracellular inclusions that are believed to be pathological....
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3117178/ https://ncbi.nlm.nih.gov/pubmed/21641323 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2011.04.028 |
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