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Examining Polyglutamine Peptide Length: A Connection between Collapsed Conformations and Increased Aggregation
Abnormally expanded polyglutamine domains in proteins are associated with several neurodegenerative diseases, of which the best known is Huntington’s. Expansion of the polyglutamine domain facilitates aggregation of the affected protein, and several studies directly link aggregation to neurotoxicity...
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| Główni autorzy: | , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2009
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2764006/ https://ncbi.nlm.nih.gov/pubmed/19699209 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.08.034 |
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