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Elongation Kinetics of Polyglutamine Peptide Fibrils: A Quartz Crystal Microbalance with Dissipation Study

Abnormally expanded polyglutamine domains in proteins are associated with several neurodegenerative diseases, including Huntington's disease. Expansion of the polyglutamine (polyQ) domain facilitates aggregation of the affected protein, and several studies directly link aggregation to neurotoxi...

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Main Authors: Walters, Robert H., Jacobson, Kurt H., Pedersen, Joel A., Murphy, Regina M.
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572748/
https://ncbi.nlm.nih.gov/pubmed/22459263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.03.017
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