The Contribution of Common CYP2A6 Alleles to Variation in Nicotine Metabolism Among European Americans

Cytochrome P450 2A6 (CYP2A6) is the primary catalyst of nicotine metabolism. To develop a predictive genetic model of nicotine metabolism, the conversion of deuterated (D(2))-nicotine to D(2)-cotinine was quantified in 189 European Americans and the contribution of CYP2A6 genotype to variability in...

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Main Authors: Bloom, A. Joseph, Hinrichs, Anthony L., Wang, Jen C., von Weymarn, Linda B., Kharasch, Evan D., Bierut, Laura J., Goate, Alison, Murphy, Sharon E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3116045/
https://ncbi.nlm.nih.gov/pubmed/21597399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e328346e8c0
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