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CYP2A6- and CYP2A13-Catalyzed Metabolism of the Nicotine Δ(5′(1′))Iminium Ion
Nicotine, the major addictive agent in tobacco, is metabolized primarily by CYP2A6-catalyzed oxidation. The product of this reaction, 5′-hydroxynicotine, is in equilibrium with the nicotine Δ(5′(1′))iminium ion and is further metabolized to cotinine. We reported previously that both CYP2A6 and the c...
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| Hoofdauteurs: | , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
The American Society for Pharmacology and Experimental Therapeutics
2012
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3477218/ https://ncbi.nlm.nih.gov/pubmed/22869927 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.195255 |
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