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Effects upon in vivo nicotine metabolism reveal functional variation in FMO3 associated with cigarette consumption

BACKGROUND: Flavin-containing monooxygenases (FMO) catalyze the metabolism of nucleophilic heteroatom containing drugs and xenobiotics including nicotine. Rare mutations in FMO3 are responsible for defective N-oxygenation of dietary trimethylamine leading to trimethylaminuria, and common genetic var...

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Detalhes bibliográficos
Publicado no:Pharmacogenet Genomics
Main Authors: Bloom, A. Joseph, Murphy, Sharon E., Martinez, Maribel, von Weymarn, Linda B., Bierut, Laura J., Goate, Alison
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583063/
https://ncbi.nlm.nih.gov/pubmed/23211429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e32835c3b48
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