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Effects upon in vivo nicotine metabolism reveal functional variation in FMO3 associated with cigarette consumption
BACKGROUND: Flavin-containing monooxygenases (FMO) catalyze the metabolism of nucleophilic heteroatom containing drugs and xenobiotics including nicotine. Rare mutations in FMO3 are responsible for defective N-oxygenation of dietary trimethylamine leading to trimethylaminuria, and common genetic var...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Pharmacogenet Genomics |
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| Κύριοι συγγραφείς: | , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2013
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4583063/ https://ncbi.nlm.nih.gov/pubmed/23211429 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e32835c3b48 |
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