CYP2B6 Non-Coding Variation Associated with Smoking Cessation Is Also Associated with Differences in Allelic Expression, Splicing, and Nicotine Metabolism Independent of Common Amino-Acid Changes

The Cytochrome P450 2B6 (CYP2B6) enzyme makes a small contribution to hepatic nicotine metabolism relative to CYP2A6, but CYP2B6 is the primary enzyme responsible for metabolism of the smoking cessation drug bupropion. Using CYP2A6 genotype as a covariate, we find that a non-coding polymorphism in C...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Bloom, A. Joseph, Martinez, Maribel, Chen, Li-Shiun, Bierut, Laura J., Murphy, Sharon E., Goate, Alison
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2013
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829832/
https://ncbi.nlm.nih.gov/pubmed/24260284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0079700
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