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A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases

INTRODUCTION: The P2X7 receptor (P2X7R) has an important role in inflammation and immunity, but until recently, clinical application has been limited by a lack of specific antagonists. Recent studies using P2X7R knockout (KO) mice and specific receptor antagonists have shown that the P2X7R is an imp...

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Autors principals: Arulkumaran, Nishkantha, Unwin, Robert J., Tam, Frederick W. K.
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3114873/
https://ncbi.nlm.nih.gov/pubmed/21510825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/13543784.2011.578068
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