The P2X7 receptor (P2X7R)-specific antagonist A804598 inhibits inflammatory reaction in human fibroblast-like synoviocytes

Activation of the P2X7 receptor (P2X7R) has been found to increase expression of tumor necrosis factor-α (TNF-α) in the joints and synovial lining of patients with rheumatoid arthritis (RA). Increased expression of TNF-α promotes joint destruction through deterioration of type II collagen by matrix...

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Bibliographic Details
Published in:Am J Transl Res
Main Authors: Liu, Yu, Wu, Yongwei, Gu, Sanjun, Yin, Qudong, Li, Haifeng, Wang, Jian, Geng, Dechun, Xu, Yaozeng
Format: Artigo
Language:Inglês
Published: e-Century Publishing Corporation 2020
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7013224/
https://ncbi.nlm.nih.gov/pubmed/32051736
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