P2X(7) receptor antagonism ameliorates renal dysfunction in a rat model of sepsis

Sepsis is a major clinical problem associated with significant organ dysfunction and high mortality. The ATP‐sensitive P2X(7) receptor activates the NLRP3 inflammasome and is a key component of the innate immune system. We used a fluid‐resuscitated rat model of fecal peritonitis and acute kidney inj...

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Detaylı Bibliyografya
Yayımlandı:Physiol Rep
Asıl Yazarlar: Arulkumaran, Nishkantha, Sixma, Marije L., Pollen, Sean, Ceravola, Elias, Jentho, Elisa, Prendecki, Maria, Bass, Paul S., Tam, Frederick. W. K., Unwin, Robert J., Singer, Mervyn
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2018
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828936/
https://ncbi.nlm.nih.gov/pubmed/29488356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13622
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