Loss of a single Hic1 allele accelerates polyp formation in Apc(Δ716) mice

Adenomatous polyposis coli (APC) gene mutations have been implicated in familial and sporadic gastrointestinal (GI) cancers. APC mutations are associated with autosomal dominant inheritance of disease in humans. Similarly, mice that contain a single mutant APC gene encoding a protein truncated at re...

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Autors principals: Mohammad, H P, Zhang, W, Prevas, H S, Leadem, B R, Zhang, M, Herman, J G, Hooker, C M, Watkins, D N, Karim, B, Huso, D L, Baylin, S B
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3114184/
https://ncbi.nlm.nih.gov/pubmed/21297660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.633
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