Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma

Medulloblastoma is an embryonal tumor thought to arise from the granule cell precursors (GCPs) of the cerebellum. PATCHED (PTCH), an inhibitor of Hedgehog signaling, is the best-characterized tumor suppressor in medulloblastoma. However, <20% of medulloblastomas have mutations in PTCH. In the sea...

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Bibliografiska uppgifter
Huvudupphovsmän: Briggs, Kimberly J., Corcoran-Schwartz, Ian M., Zhang, Wei, Harcke, Thomas, Devereux, Wendy L., Baylin, Stephen B., Eberhart, Charles G., Watkins, D. Neil
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2008
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275430/
https://ncbi.nlm.nih.gov/pubmed/18347096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1640908
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