Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma

Medulloblastoma is an embryonal tumor thought to arise from the granule cell precursors (GCPs) of the cerebellum. PATCHED (PTCH), an inhibitor of Hedgehog signaling, is the best-characterized tumor suppressor in medulloblastoma. However, <20% of medulloblastomas have mutations in PTCH. In the sea...

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Detalhes bibliográficos
Main Authors: Briggs, Kimberly J., Corcoran-Schwartz, Ian M., Zhang, Wei, Harcke, Thomas, Devereux, Wendy L., Baylin, Stephen B., Eberhart, Charles G., Watkins, D. Neil
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2008
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275430/
https://ncbi.nlm.nih.gov/pubmed/18347096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1640908
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