A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1

The tumor suppressor gene HYPERMETHYLATED IN CANCER 1 (HIC1), which encodes a transcriptional repressor, is epigenetically inactivated in various human cancers. Here, we show that HIC1 is a direct transcriptional repressor of the gene encoding ephrin-A1, a cell surface ligand implicated in the patho...

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Detalhes bibliográficos
Main Authors: Zhang, Wei, Zeng, Xiaobei, Briggs, Kimberly J, Beaty, Robert, Simons, Brian, Yen, Ray-Whay Chiu, Tyler, Megan A, Tsai, Hsing-Chen, Ye, Ying, Gesell, Gregory S, Herman, James G, Baylin, Stephen B, Watkins, D Neil
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3025282/
https://ncbi.nlm.nih.gov/pubmed/20154726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.12
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