Regulation of sonic hedgehog-GLI1 downstream target genes PTCH1, Cyclin D2, Plakoglobin, PAX6 and NKX2.2 and their epigenetic status in medulloblastoma and astrocytoma

BACKGROUND: The Sonic hedgehog (Shh) signaling pathway is critical for cell growth and differentiation. Impairment of this pathway can result in both birth defects and cancer. Despite its importance in cancer development, the Shh pathway has not been thoroughly investigated in tumorigenesis of brain...

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Detalhes bibliográficos
Main Authors: Shahi, Mehdi H, Afzal, Mohammad, Sinha, Subrata, Eberhart, Charles G, Rey, Juan A, Fan, Xing, Castresana, Javier S
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2989332/
https://ncbi.nlm.nih.gov/pubmed/21059263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-614
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