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RyRCa(2+) Leak Limits Cardiac Ca(2+) Window Current Overcoming the Tonic Effect of Calmodulin in Mice
Ca(2+) mediates the functional coupling between L-type Ca(2+) channel (LTCC) and sarcoplasmic reticulum (SR) Ca(2+) release channel (ryanodine receptor, RyR), participating in key pathophysiological processes. This crosstalk manifests as the orthograde Ca(2+)-induced Ca(2+)-release (CICR) mechanism...
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Main Authors: | , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Public Library of Science
2011
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3108979/ https://ncbi.nlm.nih.gov/pubmed/21673970 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020863 |
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