Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants

The flexible flaps and the 80s loops (Pro79–Ile84) of HIV-1 protease are crucial in inhibitor binding. Previously, it was reported that the crystal structure of multidrug-resistant 769 (MDR769) HIV-1 protease shows a wide-open conformation of the flaps owing to conformational rigidity acquired by th...

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Hlavní autoři: Yedidi, Ravikiran S., Proteasa, Georghe, Martinez, Jorge L., Vickrey, John F., Martin, Philip D., Wawrzak, Zdzislaw, Liu, Zhigang, Kovari, Iulia A., Kovari, Ladislau C.
Médium: Artigo
Jazyk:Inglês
Vydáno: International Union of Crystallography 2011
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107050/
https://ncbi.nlm.nih.gov/pubmed/21636892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444911011541
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