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Polyamine-linked oligonucleotides for DNA triple helix formation.

The concept of antigene therapy of disease is based on the ability of an oligonucleotide (the therapeutic agent) to bind to double-stranded genomic DNA (the target associated with the disease). Examples are herein given of the linkage of a series of polyamines to a 21-mer homopyrimidine oligonucleot...

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Bibliografske podrobnosti
Main Authors: Tung, C H, Breslauer, K J, Stein, S
Format: Artigo
Jezik:Inglês
Izdano: 1993
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC310591/
https://ncbi.nlm.nih.gov/pubmed/8265366
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