Oct4-Induced Reprogramming Is Required for Adult Brain Neural Stem Cell Differentiation into Midbrain Dopaminergic Neurons

Neural stem cells (NSCs) lose their competency to generate region-specific neuronal populations at an early stage during embryonic brain development. Here we investigated whether epigenetic modifications can reverse the regional restriction of mouse adult brain subventricular zone (SVZ) NSCs. Using...

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Detalhes bibliográficos
Main Authors: Deleidi, Michela, Cooper, Oliver, Hargus, Gunnar, Levy, Adam, Isacson, Ole
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104995/
https://ncbi.nlm.nih.gov/pubmed/21655272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019926
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