Intrastriatal Transforming Growth Factor α Delivery to a Model of Parkinson's Disease Induces Proliferation and Migration of Endogenous Adult Neural Progenitor Cells without Differentiation into Dopaminergic Neurons

We examined the cell proliferative, neurogenic, and behavioral effects of transforming growth factor α (TGFα) in a 6-OHDA Parkinson's disease model when compared with naive rats. Intrastriatal TGFα infusion induced significant proliferation, hyperplastic nodules, and substantial migratory waves...

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Hlavní autoři: Cooper, Oliver, Isacson, Ole
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2004
Témata:
Neurobiology of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2613225/
https://ncbi.nlm.nih.gov/pubmed/15483111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2344-04.2004
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