Oct4-Induced Reprogramming Is Required for Adult Brain Neural Stem Cell Differentiation into Midbrain Dopaminergic Neurons

Neural stem cells (NSCs) lose their competency to generate region-specific neuronal populations at an early stage during embryonic brain development. Here we investigated whether epigenetic modifications can reverse the regional restriction of mouse adult brain subventricular zone (SVZ) NSCs. Using...

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Hlavní autoři: Deleidi, Michela, Cooper, Oliver, Hargus, Gunnar, Levy, Adam, Isacson, Ole
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104995/
https://ncbi.nlm.nih.gov/pubmed/21655272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019926
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