SYNTHESIS, METABOLIC STABILITY AND ANTIVIRAL EVALUATION OF VARIOUS ALKOXYALKYL ESTERS OF CIDOFOVIR AND (S)-[3-HYDROXY-2-(PHOSPHONOMETHOXY)PROPYL]ADENINE

Alkoxyalkyl esters of cidofovir (CDV) are orally active agents which inhibit the replication of a variety of double stranded DNA (dsDNA) viruses including variola, vaccinia, ectromelia, herpes simplex virus, cytomegalovirus, adenovirus and others. One of these compounds, hexadecyloxypropyl-CDV (HDP-...

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Bibliographische Detailangaben
Hauptverfasser: Ruiz, Jacqueline, Beadle, James R., Buller, R. Mark, Schreiwer, Jill, Prichard, Mark N., Keith, Kathy A., Lewis, Kenneth C., Hostetler, Karl Y.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104040/
https://ncbi.nlm.nih.gov/pubmed/21493074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.03.034
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