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Potential role of cathepsin K in the pathophysiology of mucopolysaccharidoses

Cathepsin K, a papain-like cysteine protease, is highly expressed in osteoclasts and plays a critical role in bone resorption. Dysfunction of the enzyme leads to various skeletal abnormalities. The recent knowledge that the collagenolytic activity of cathepsin K depends on interactions with bone and...

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Bibliografske podrobnosti
Main Authors: Wilson, Susan, Brömme, Dieter
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103771/
https://ncbi.nlm.nih.gov/pubmed/21629671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/PRM-2010-0116
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