Highly Sulfated Nonreducing End-derived Heparan Sulfate Domains Bind Fibroblast Growth Factor-2 with High Affinity and Are Enriched in Biologically Active Fractions

Human fibroblast growth factor-2 (FGF2) regulates cellular processes including proliferation, adhesion, motility, and angiogenesis. FGF2 exerts its biological function by binding and dimerizing its receptor (FGFR), which activates signal transduction cascades. Effective binding of FGF2 to its recept...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Naimy, Hicham, Buczek-Thomas, Jo Ann, Nugent, Matthew A., Leymarie, Nancy, Zaia, Joseph
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2011
Gaiak:
Glycobiology and Extracellular Matrices
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103309/
https://ncbi.nlm.nih.gov/pubmed/21471211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.204693
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