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Highly Sulfated Nonreducing End-derived Heparan Sulfate Domains Bind Fibroblast Growth Factor-2 with High Affinity and Are Enriched in Biologically Active Fractions

Human fibroblast growth factor-2 (FGF2) regulates cellular processes including proliferation, adhesion, motility, and angiogenesis. FGF2 exerts its biological function by binding and dimerizing its receptor (FGFR), which activates signal transduction cascades. Effective binding of FGF2 to its recept...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Naimy, Hicham, Buczek-Thomas, Jo Ann, Nugent, Matthew A., Leymarie, Nancy, Zaia, Joseph
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103309/
https://ncbi.nlm.nih.gov/pubmed/21471211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.204693
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