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Highly Sulfated Nonreducing End-derived Heparan Sulfate Domains Bind Fibroblast Growth Factor-2 with High Affinity and Are Enriched in Biologically Active Fractions

Human fibroblast growth factor-2 (FGF2) regulates cellular processes including proliferation, adhesion, motility, and angiogenesis. FGF2 exerts its biological function by binding and dimerizing its receptor (FGFR), which activates signal transduction cascades. Effective binding of FGF2 to its recept...

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Bibliografische gegevens
Hoofdauteurs: Naimy, Hicham, Buczek-Thomas, Jo Ann, Nugent, Matthew A., Leymarie, Nancy, Zaia, Joseph
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103309/
https://ncbi.nlm.nih.gov/pubmed/21471211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.204693
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