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Dual and opposing roles of the unfolded protein response regulated by IRE1α and XBP1 in proinsulin processing and insulin secretion

As a key regulator of the unfolded protein response, the transcription factor XBP1 activates genes in protein secretory pathways and is required for the development of certain secretory cells. To elucidate the function of XBP1 in pancreatic β-cells, we generated β-cell-specific XBP1 mutant mice. Xbp...

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מידע ביבליוגרפי
Main Authors: Lee, Ann-Hwee, Heidtman, Keely, Hotamisligil, Gökhan S., Glimcher, Laurie H.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102350/
https://ncbi.nlm.nih.gov/pubmed/21555585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1105564108
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