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The nuclear RNA polymerase II surveillance system targets polymerase III transcripts

A key question in nuclear RNA surveillance is how target RNAs are recognized. To address this, we identified in vivo binding sites for nuclear RNA surveillance factors, Nrd1, Nab3 and the Trf4/5–Air1/2–Mtr4 polyadenylation (TRAMP) complex poly(A) polymerase Trf4, by UV crosslinking. Hit clusters wer...

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Hlavní autoři: Wlotzka, Wiebke, Kudla, Grzegorz, Granneman, Sander, Tollervey, David
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102002/
https://ncbi.nlm.nih.gov/pubmed/21460797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.97
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